Proteome Research: Mass Spectrometry
نویسندگان
چکیده
منابع مشابه
Mass spectrometry of the proteome.
Biological polymers undergo numerous significant and fascinating interactions, such as post-translational modifications, noncovalent associations, and conformational changes. A valuable parameter for the characterization of a biopolymer is molecular mass (MM). The field of mass spectrometry (MS) has evolved rapidly in the last decade through the introduction of two ionization techniques, matrix...
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Tumor genomes accumulate a large number of rearrangements many of which contribute to tumor progression and lead to formation of novel fusion genes resulting in oncogenic activities (Gray and Collins 2000 [1]). Identification of fusion genes has contributed significantly to our understanding of cancer progression , yielding important predictive markers and targets for therapeutic intervention s...
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Proteome characterization using mass spectrometry is essential for the systematic investigation of biological systems and for the study of gene function. Recent advances in this multifaceted field have occurred in four general areas: protein and peptide separation methodologies; selective labeling chemistries for quantitative measurement of peptide and protein abundances; characterization of po...
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1 Principles and Instrumentation 3 1.1 Proteome and Proteomics 3 1.2 Need for Large-scale Analyses of Gene Products at the Protein Level 3 1.3 General Problems in Proteome Analyses 4 1.4 MS Instrumentation 5 1.4.1 Ionization Methods 6 1.4.2 Mass Analyzers 8 1.4.3 MS/MS 9 1.5 Methods of Sample Fractionation 10 1.5.1 2D-electrophoretic Separation of Complex Protein Mixtures 11 1.5.2 Liquid-phase ...
متن کاملReview of a current role of mass spectrometry for proteome research.
This review is intended to give readers a snapshot of current mass spectrometry for proteomics research. It covers a brief history of mass spectrometry proteomic research, peptidomics and proteomics for biomarker search, quantitative proteomics, proteomics with post-translational modification and future perspective of proteomics.
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ژورنال
عنوان ژورنال: Journal of Proteome Research
سال: 2002
ISSN: 1535-3893,1535-3907
DOI: 10.1021/pr0203215